Hard-to-heal wounds, such as venous leg ulcers (VLUs), are a major challenge to healthcare systems globally⁵

• Estimated prevalence of ~1.9 per 1000 population^6,7
• Associated with reduced patient health-related quality of life and substantial economic burden^8,9

Biofilm has long been implicated in hard-to-heal wounds¹⁰

• At least 78% of hard-to-heal wounds are estimated to have biofilm¹¹
• Biofilm can protect microorganisms from antibiotics, antiseptics and host immunity¹⁰

Aquacel^® Ag+ Extra™ is a gelling fibre dressing with antibiofilm properties⁴

• Indicated for moderate to highly exuding hard-to-heal and acute wounds with infection or an increased risk of infection¹²
• Contains BEC and EDTA which work synergistically with iconic silver to disrupt and destroy biofilm⁴

PRIMARY

• Complete wound closure of week 12 (100% surface epithelialization)

SECONDARY

• Percent change in wound area (week 4 & 12)
• Satisfactory clinical progress (40% wound area reduction at week 4)

EXPLORATORY

• Time to complete wound closure

SAFETY

• Adverse events (AEs)
• Device-related AEs

• The mean wound area was 10.2cm² in Aquacel^® Ag+ Extra™ arm compared with 17.32 in the DACC arm.
• In Aquacel^® Ag+ Extra™ arm, six patients had wound infection at baseline (no patients in the DACC arm had infection).

• Exudate volume on both arms were recorded evenly.

• Majority of tissue type in both arms is slough/fibrin and healthy granulation.

• Aquacel^® Ag+ Extra™ was associated with statistically significantly increased rate of complete wound closure at week 12 compared to DACC dressings, as well we a faster time to complete wound closure
• VLUs treated with Aquacel^® Ag+ Extra™ had a 35% increased likelihood of complete wound closure compared to DACC dressings at 12 weeks

• Aquacel^® Ag+ Extra™ a resulted in a significantly greater percentage reduction in wound area compared to DACC dressings.

• Aquacel^® Ag+ Extra™ was a safe treatment option with no serious of concern dressing-related AEs

• Improved quality of life (QoL) with significantly higher rate of satisfactory clinical progress¹³
• Aquacel^® Ag+ Extra™ a had a 19% increased likelihood of satisfactory clinical progress compared to DACC dressings